题 目：Controlling molecular complexity and design of bio-inspired materials and catalysts 报告人： Roeland J.M. Nolte Radboud University, Institute for Molecules and Materials, Cluster for Molecular Chemistry, Heyendaalseweg 125, 6525AJ Nijmegen, The Netherlands 时 间：2015年10月13号（星期二）下午 15:00分 地 点：仙林化学楼 H201 报告厅 E-mail： R.Nolte@science.ru.nl In this lecture I will discuss some of our work in the field of bio-inspired complex molecular systems. In the first part I will describe the properties of polyisocyanopeptides, which are rigid protein-like polymers having a helical beta-sheet structure. Our recent efforts to measure the stiffness of these polymers, e.g. by real time single molecule diffusion studies (reptation experiments) will be presented. The stiffness and regular structure of the polymers has been used to prepare materials with complex features. For instance, polyisocyanopeptides with ethylene glycol side chains form gels at extremely low concentrations, displaying properties similar to those of the complex intra- and extra-cellular matrices in nature, e.g. strain stiffening. The possibilities to control the properties of the gels, using the stiffness of the single chains as a design parameter, and their use as matrices for the growth and differentiation of stem cells will be discussed. |