报告题目：Charm and fascination of dendrimer nanotechnology in biomedical applications 报告人：彭玲教授（Ling PENG），法国CNRS研究员 Centre Interdisciplinaire de Nanoscience de Marseille, CNRS, Aix-Marseille University, France 时间: 2015年8月21号（星期五）上午10:30 地点：化学楼3楼报告厅 邀请人： 王乐勇教授，lywang@nju.edu.cn, 83592529 (office) Biographical sketch E-mail: ling.peng@univ-amu.fr Dr. Ling Peng is a research director at the French National Scientific Research Center (CNRS). She carried her undergraduate study in polymer chemistry with Prof. Chen Rongshi at Nanjing University in China, her Ph.D program in organic chemistry with Prof. Albert Eschenmoser at Swiss Federal Institute of Technology in Zurich Switzerland, and her postdoctoral research with Prof. Maurice Goeldner in Pharmacy at Louis Pasteur University of Strasbourg in France. She was recruited as a research scientist in CNRS in 1997, and promoted as a CNRS research director in 2008. She is currently a group leader at the Interdisciplinary Center on Nanoscience in Marseille in France, and working actively in developing multifunctional dendrimers as intelligent nanomaterials for drug and gene delivery, molecular probes for exploring biological events and drug discovery. Dr. Ling Peng has been actively involved in the European COST Actions of “Biological Applications of Dendrimers” and “Targeting Drug Resistance of Cancer Stem Cells”, and coordinated a European project entitled “Dendrimers as nanovectors for targeted siRNA delivery in gene therapy”. She has co-authored more than 100 scientific papers, 5 patents and 13 book chapters. Dr. Ling Peng is the member of Editorial Advisory Board of Molecular Pharmaceutics, section editor for drug delivery of Current Medicinal Chemistry and Assistant Editor of New Journal of Chemistry. Distinctions: 1. Prix Dai An-Bang 1986, Nanjing University, P. R. China 2. Lungen Stipendia Award 1989 - 1992, Swiss Federal Institute of Polytechnique in Zurich, Switzerland 3. Prix Roussel 1996 de la Société Française de la Photobiologie, France 4. Cheung Kong Scholar, 2000-2003, P. R. China 5. Luojia Visiting Scholar at Wuhan University 2003-2010, P. R. China 6. Excellent CNRS research scientist price, 2011-2014, France 7. Visiting Lecturer at Chemistry Promotion Center of Ministry of Science and Technology, Taiwan, 2014 Current Research Interests - Functional Dendrimers for Nucleic Acid and Drug Delivery - Chemistry and Biology of Triazole Nucleosides - Molecular Probes and Chemical Biology Administration Editorial Advisory Board of Molecular Pharmaceutics Section Editor of Curr. Med. Chem. Assistant Editor of New Journal of Chemistry Management Committee of the European COST Action TD0802 Coordinator of EU FP7 “EuroNanoMed” project of DENANORNA Co-chairman of the 2nd International Symposium of Biological Applications of Dendrimers, Porquerolle, France, June 23-26, 2010 Chairman of the Organization Committee of RCOM5 (2008), Marseille, France Scientific Committee of the 3rd (2012) and 4th (2014) International Symposium of Biological Applications of Dendrimers External expert for French National Research Agency, European Science Foundation, Medical Research Council of United Kingdom, Research Grants Council of Hong Kong, Polish Science Foundation, Natural Science Foundation of China Publications: 105 papers; 5 patents; 1 book; 13 book chapters Selected publications: 1. Laurent S, Chen H, Bedu S, Ziarelli F, Peng L, Zhang CC. Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 9907-9912. (Cover Story) 2. Yu T, Liu X, Bolcato-Bellemin A-L, Wang Y, Liu C, Erbacher P, Qu F, Rocchi P, Behr J-P, Peng L. Angew. Chem. Int. Ed. 2012, 51, 8478-8484. (Frontispiece) 3. Xia Y, Peng L. Chem. Rev. 2013, 113, 7880 � 7929 (Cover Story). 4. Liu X, Zhou J, Yu T, Chen C, Cheng Q, Sengupta K, Huang Y, Li H, Liu C, Wang Y, Posoco P, Wang M, Cui Q, Giorgio S, Fermeglia M, Qu F, Pricl S, Shi Y, Liang C, Rocchi P, Rossi JJ, Peng L. Angew. Chem. Int. Ed. 2014, 53, 11822-11827. (Highlighted in Nature Chemistry) 5. Wei T, Chen C, Liu J, Liu C, Posocco P, Liu X, Cheng Q, Huo S, Liang Z, Fermeglia M, Pricl S, Liang X-J, Rocchi P, Peng L. Proc Natl Acad Sci U S A, 2015, 112, 2978. Abstract for Lecture The application of nanotechnology to engineer nanovectors for drug delivery is widely expected to bring breakthrough in nanomedicine and create entirely novel therapeutics. Dendrimers are ideal nanocarriers for drug delivery by virtue of their uniquely well-defined and precisely controlled structure as well as the multivalent cooperativity confined within nanosized volume.1 We have developed covalently constructed flexible dendrimers2-3 for nuclei acid delivery, one of which has been scheduled in clinical trial in USA and UK.4-5 Recently, we have established self-assembled non-covalent supramolecular dendrimers as excellent nanocarriers for nucleic acid and drug delivery. In particular, self-assembling amphiphilic dendrimers are able to form adaptive supramolecular nanostructures,5-6 which encapsulate anticancer molecules with high loading efficiency for effective drug delivery to combat drug resistance.7 Our studies opens new perspectives in molecular engineering of functional materials in nanotechnology and biomedical applications. 1. “Dendrimers in Biomedical Applications”, Eds: B. Klajnert, L. Peng, V. Cena, RSC Publishing, 2013, ISBN: 978-1-84973-611-4 2. Zhou J, Wu J, Hafdi N, Behr J-P, Erbacher P, Peng L, Chem. Commun. 2006, 2362-2364; 3. Liu X, Liu C, Catapano C, Peng L, Zhou J, Rocchi P, Biotechnology Advances 2014, 32, 844-852. 4. Zhou J, Neff P, Liu X, Zhang J, Li H, Smith D, Swiderski P, Huang Y, Du Q, Liang Z, Peng L, Akkina R, Rossi J, Mol. Ther. 2011, 19, 2228-2238 5. Reebye V, Sætrom P, Mintz P, Huang K-W, Swiderski P, Peng L, Liu C, Liu X, Lindkaer-Jensen S, Zacharoulis D, Kostomitsopoulos N, Kasahara N, Nicholls J, Jiao L, Pai M, Spalding D, Mizandari M, Chikovani T, Emara M, Haoudi A, Tomalia D, Rossi J, Habib N, Hepatology 2014, 59, 216-227 6. Liu X, Zhou J, Yu T, Chen C, Cheng Q, Sengupta K, Huang Y, Li H, Liu C, Wang Y, Posocco P, Wang M, Cui Q, Giorgio S, Fermeglia M, Qu F, Pricl S, Shi Y, Liang Z, Rocchi P, Rossi JJ, Peng L, Angew. Chem. Int. Ed., 2014, 53, 11822; 7. Yu T, Liu X, Bolcato-Bellemin A-L, Wang Y, Liu C, Erbacher P, Qu F, Rocchi P, Behr J-P, Peng L, Angew. Chem. Int. Ed. 2012, 51, 8478-8484. 8. Wei T, Chen C, Liu J, Liu C, Posocco P, Liu X, Cheng Q, Huo S, Liang Z, Fermeglia M, Pricl S, Liang XJ, Rocchi P, Peng L, Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 2978. |