报告题目：Chemically Modified siRNAs that Make Sense 报 告 人：Prof. Jean-Paul Desaulniers 报告单位：University of Ontario Institute of Technology, Canada. 报告时间：2015年7月13日(星期一) 下午3:30 报告地点：化学楼三楼报告厅摘要: Aberrant gene expression is a hallmark of disease and targeting messenger RNA through RNA interference is a promising approach to reduce the expression of deleterious proteins. However, some of the current problems associated with using oligonucleotides as therapeutics include off�target toxicity, chemical lability, and poor cellular delivery. Many of these challenges are attributed to the native negatively charged phosphodiester backbone of the oligonucleotide. As such, our current interest in overcoming these obstacles involves chemical modification of the backbone with neutral unnatural functional groups. In particular, we have interest in designing and modifying siRNAs bearing triazole functionalities. This talk will focus on many of the types of chemical modifications that our group has been working on over the last few years that are compatible within the RNAi machinery. This development will allow for future chemical investigations that are compatible within the RNAi pathway. 教育与研究经历： Jean-Paul Desaulniers was born and raised in London Ontario. He studied Chemistry and Biochemistry at the University of Western Ontario and received his Honors B.Sc. in 2000. He entered graduate school at Wayne State University, under the guidance of Prof. Chow, and he received his Ph.D. from Wayne State University in 2005. His thesis work focused on synthesizing and studying naturally occurring modified RNAs found within the ribosome. After his Ph.D., he studied at the University of Michigan, where he worked under the guidance of Prof. Mapp. During his time, he was awarded an American Cancer Society Postdoctoral Fellowship and focused his work in chemical biology on studying small organic molecule transcription factor mimics. Since the fall of 2008, Jean-Paul started as an assistant professor in chemistry, and was promoted in 2013 to an associate professor. His research at UOIT focuses on developing unnatural scaffolds that are capable of controlling gene expression. 伟德源自英国始于1946 生命化学协同创新中心 配位化学国家重点实验室 |