报告题目：Probing the “nano-bio” interactions between DNA-based nanostructures and the cell
报告人：Dr. Chung Hang Jonathan CHOI
Department of Electronic Engineering (Biomedical Engineering), the Chinese University of Hong Kong
时间：2015年3月30号（星期一）上午10:00
地点：唐仲英楼B501
联系人：沈珍教授，zshen@nju.edu.cn,83686679 摘要:
Intracellular delivery of nucleic acids as gene regulation agents typically requires the use of cationic carriers or viral vectors, yet issues related to cellular toxicity or immune responses hamper their attractiveness as therapeutic candidates. The discovery that spherical nucleic acids (SNAs), polyanionic structures comprised of densely packed DNA oligonucleotides covalently attached to the surface of a nanoparticle core, can effectively enter more than 50 different cell types presents a potential strategy for overcoming the limitations of conventional transfection agents. This presentation will explore how SNAs fundamentally interact with cells from three different perspectives. These results reinforce the notion that SNAs can serve as therapeutic payloads and targeting structures to engage biological pathways not readily accessible with linear oligonucleotides. 报告人简介:
E-mail：jchchoi@ee.cuhk.edu.hk
Research field: nanomedicine, “bio-nano” interactions, bio-inspired nanomaterials, imaging
Publication: Since 2009, he has published more than 14 papers on top journals including Nat. Mater., Adv. Mater., Sci. Tansl. Med., Proc. Nat. Acad. Sci. USA., Small and J. Control.Release and two patents. H-index = 10. Total number of citations > 1300.
Awards:
The Croucher Foundation: Start-up Allowance 2014
Kellogg School of Management, Northwestern University: Business for Scientists Certificate 2013
American Institute of Chemical Engineers: Bionanotechnology Graduate Student Award - 2nd Prize 2010
Chemical Engineering, California Institute of Technology: Constantin G. Economou Memorial Prize 2008
Department of Chemical Engineering, Stanford University: Mason and Marsden Prize 2005
American Institute of Chemical Engineers (NorCal Section): Outstanding Senior at Stanford University 2005
School of Engineering, Stanford University: Summer Undergraduate Research Fellowship 2003
The Associated Board of the Royal Schools of Music: Advanced Certificate (Violin)2000 配位化学国家重点实验室 |
