研究生专题报告

题   目：From Circular Proteins to Regenerative Medicine and Optogenetics: Development of New Biomaterials and Biosensors by Protein Engineering
报告人：Prof. Fei SUN
时   间：2014.12.29 (星期一)上午10点
地   点：化学楼三楼报告厅

报告人简介： Dr. Sun is currently an assistant professor at the Department of Chemical and Biomolecular Engineering, Hong Kong University of Science and Technology. His current research aims to apply directed evolution and other protein engineering methods to develop genetically encoded chemistries for materials science, optogenetics and neuroscience. From 2012 to 2014, he was a postdoctoral researcher at the Department of Chemical Engineering at Caltech working with Professor Frances H. Arnold on directed evolution and protein engineering. He got his B.S. degree in Chemistry at Peking University in 2007, and completed his Ph.D. degree at the University of Chicago in 2012, with the work recognized by several awards (e.g., Chicago Biomedical Consortium Scholar Award, The Everett E. Gilbert Memorial Prize in Organic Chemistry, etc.).

报告摘要:
The synthesis of molecular systems with atomic precision for a specific application constitutes a fundamental challenge of molecular engineering. Development of the ability to construct complex biomolecular architectures will provide a solution to overcome this obstacle. Genetically encoded click chemistry, e.g. SpyTag-SpyCatcher chemistry, which can covalently link two protein molecules together with high specificity and efficiency, enables precise control over macromolecule topology, synthesis of bioactive biomaterials, design of improved biocatalysts, and biomolecular imaging, thus representing a powerful tool for molecular engineering.